Open innovation is a growing phenomenon. Recent studies show that, for large European and US companies: 78 per cent report practicing open innovation; none report having abandoned the approach; and 82 per cent of practicing companies have increased their focus on open innovation. But what is stopping all companies from taking up the benefits of open innovation? The new ‘paradigm’ of open innovation means changes right across the organization. Here, we look at the arguably the most important of these – company culture – and how to address cultural barriers to open innovation.